IL6R — Interleukin 6 receptor
IL6R belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
IL6R's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Tfh program B cell help | BAZ2B, CCDC50, CDK5R1, CXCR5, LY96, MTUS1, PASK, PIP4P2 +10 more | View in SCUBA |
| Endothelial | Endothelial Barrier Homeostasis migration & adhesion | AFDN, CD2AP, CLEC3B, ENPP2, IFNGR1, ITGB4, JAM2, LIFR +11 more | View in SCUBA |
| Enterocytes | Long-gene Nuclear Transcripts Technical artifact | ABCA10, ABCA5, ADCY9, EXOC6B, GABRA2, INSR, MAGI1, MBNL1 +6 more | View in SCUBA |
| Hematopoietic progenitor cells | Multipotent Progenitor State Stemness | CD44, CD99, FLT3, GBP2, GLIPR1, PLCB1, PRAM1, PROM1 | |
| Macrophages | mRNA Splicing Processing Housekeeping | ACIN1, ARID3A, BOD1L1, CCNL2, CDK12, CLK4, DCP2, GPATCH2L +20 more | View in SCUBA |
About the gene
| Synonyms | CD126, gp80, IL-1Ra, IL-6R, IL6RA |
|---|---|
| Chromosome | 1: 154405193-154469450 |
| Predicted location | Intracellular, Membrane, Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Candidate cardiovascular disease genes, CD markers, Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins |
| Molecular function | Receptor |
Function
Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation leads to the regulation of the immune response, acute-phase reactions and hematopoiesis. The interaction with membrane-bound IL6R and IL6ST stimulates 'classic signaling', the restricted expression of the IL6R limits classic IL6 signaling to only a few tissues such as the liver and some cells of the immune system. Whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans- signaling'. Alternatively, 'cluster signaling' occurs when membrane- bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells (Probable). Signaling via the membrane-bound IL6R is mostly regenerative and anti-inflammatory (Probable). Drives naive CD4(+) T cells to the Th17 lineage, through 'cluster signaling' by dendritic cells (By similarity). Soluble form of IL6 receptor (sIL6R) that acts as an agonist of IL6 activity. The IL6:sIL6R complex (hyper-IL6) binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL6R in a process called IL6 'trans-signaling'. sIL6R is causative for the pro- inflammatory properties of IL6 and an important player in the development of chronic inflammatory diseases. In complex with IL6, is required for induction of VEGF production. Plays a protective role during liver injury, being required for maintenance of tissue regeneration (By similarity). 'Trans-signaling' in central nervous system regulates energy and glucose homeostasis (By similarity). Soluble form of IL6 receptor (sIL6R) that acts as an agonist of IL6 activity. The IL6:sIL6R complex (hyper-IL6) binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL6R in a process called IL6 'trans- signaling'. sIL6R is causative for the pro-inflammatory properties of IL6 and an important player in the development of chronic inflammatory diseases. In complex with IL6, is required for induction of VEGF production. Plays a protective role during liver injury, being required for maintenance of tissue regeneration (By similarity). 'Trans-signaling' in central nervous system regulates energy and glucose homeostasis (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.