CMTM4 — CKLF like MARVEL transmembrane domain containing 4
CMTM4 belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CMTM4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | Mitochondrial Membrane Dynamics Mitochondrial & OxPhos | ASAP3, CASD1, CYP2J2, EXPH5, FAR1, MATN2, NEO1, NNT +4 more | View in SCUBA |
About the gene
| Synonyms | CKLFSF4 |
|---|---|
| Chromosome | 16: 66614750-66696743 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins, Transporters |
Function
Acts as a backup for CMTM6 to regulate plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. May protect PD- L1/CD274 from being polyubiquitinated and targeted for degradation
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.