NEO1 — Neogenin 1
NEO1 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NEO1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Th17/MAIT type-17 Th17 fate | AKT1S1, CA10, CA2, CCL20, CEBPD, GFPT2, IL22, IL4I1 +9 more | View in SCUBA |
| Enterocytes | Apicobasal polarity Migration & adhesion | ANK3, BRINP3, CHPT1, FOXP1, MCTP2, PARD3B, VAV3 | View in SCUBA |
| Gamma-delta T cells | ER Protein Translocation Protein processing & ER | ATG2A, BEST1, CLSTN1, CTDSP2, GALC, GSE1, HAPSTR1, HOOK2 +12 more | |
| Innate lymphoid cells | ER Stress UPR Stress | ERN1, HLA-DPA1, HLA-DRA, IL7R, PRKCA, SELENOM | View in SCUBA |
| Mucosal-associated invariant T cell | IL-18 Innate Activation Inflammation | ADAM10, COLQ, IL18RAP, KIF5C, ME1, MYBL1, P2RY14, PARP8 +3 more | |
| Smooth muscle cells | Microfibril ECM Assembly ECM remodeling | ADAM28, FBN2, ITGA9, NID1, PROM1, PSD3, SERPINE2, SPON1 +2 more | View in SCUBA |
About the gene
| Synonyms | HsT17534, IGDCC2, NGN, NTN1R2 |
|---|---|
| Chromosome | 15: 73051710-73305205 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, Plasma proteins, Predicted membrane proteins |
| Biological process | Cell adhesion |
Function
Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.