Mitochondrial Membrane Dynamics
Gene co-expression module in Colonocytes
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 13 genes have a known function matching the annotation |
Why this annotation
This module is heterogeneous (strong coherence but mixed biology). OPA1 (mitochondrial inner membrane fusion GTPase), NNT (mitochondrial NADPH production), FAR1 (fatty acyl-CoA reductase, ether lipid/peroxisomal), CYP2J2 (epoxygenase, arachidonic acid metabolism), PTAR1 (prenylcysteine oxidase) represent mitochondrial and lipid metabolic functions consistent with the neighboring OxPhos modules. MATN2 (ECM matrilin), NEO1 (neogenin/BMP receptor), CASD1 (sialyltransferase), CMTM4, EXPH5, ASAP3 are more diverse. PRLR (prolactin receptor) is enriched in crypt colonocytes. The module is downregulated in inflammation. Given the mitochondrial neighborhood and the presence of OPA1, NNT, FAR1, CYP2J2, the core program appears to be mitochondrial membrane dynamics and lipid metabolism, though the module is mixed.
Genes
Most correlated modules
- Mitochondrial Biogenesis · correlation 0.92
- Colonocyte Differentiation · correlation 0.91
- Crypt Colonocyte Identity · correlation 0.87
- Oxidative Phosphorylation · correlation 0.86
- Mitochondrial Peroxisomal Metabolism · correlation 0.86
- Oxidative Phosphorylation · correlation 0.83
- Colonocyte HOX Identity · correlation 0.79
- Spliceosome Assembly · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.