CNOT11 — CCR4-NOT transcription complex subunit 11
CNOT11 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CNOT11's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | mRNA Splicing Regulation RNA processing & translation | CNOT4, CPNE1, CREB1, GATAD1, GTF2A1, LMBRD1, LUC7L3, METTL23 +10 more |
About the gene
| Synonyms | C2orf29, C40 |
|---|---|
| Chromosome | 2: 101252886-101270316 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | RNA-mediated gene silencing, Transcription, Transcription regulation, Translation regulation |
Function
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is required for the association of CNOT10 with the CCR4-NOT complex. Seems not to be required for complex deadenylase function
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.