LMBRD1 — LMBR1 domain containing 1
LMBRD1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LMBRD1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Interferon Response Anti-viral | ACAP1, ARHGAP15, BCL2, CD44, CD46, DSE, EML4, FCGR2B +7 more | View in SCUBA |
| Gamma-delta T cells | mRNA Splicing Regulation RNA processing & translation | CNOT11, CNOT4, CPNE1, CREB1, GATAD1, GTF2A1, LUC7L3, METTL23 +10 more |
About the gene
| Synonyms | bA810I22.1, C6orf209, cblF, FLJ11240 |
|---|---|
| Chromosome | 6: 69672757-69867236 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters |
| Molecular function | Developmental protein |
| Biological process | Endocytosis, Gastrulation, Host-virus interaction, Transport |
Function
Lysosomal membrane chaperone required to export cobalamin (vitamin B12) from the lysosome to the cytosol, allowing its conversion to cofactors. Targets ABCD4 transporter from the endoplasmic reticulum to the lysosome. Then forms a complex with lysosomal ABCD4 and cytoplasmic MMACHC to transport cobalamin across the lysosomal membrane. Acts as an adapter protein which plays an important role in mediating and regulating the internalization of the insulin receptor (INSR) (By similarity). Involved in clathrin-mediated endocytosis of INSR via its interaction with adapter protein complex 2 (By similarity). Essential for the initiation of gastrulation and early formation of mesoderm structures during embryogenesis (By similarity). (Microbial infection) May play a role in the assembly of hepatitis delta virus (HDV)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.