mRNA Splicing Regulation
Gene co-expression module in Gamma-delta T cells
| Category | RNA processing & translation |
|---|---|
| Genes | 19 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 19 genes have a known function matching the annotation |
Why this annotation
Hub genes ZRANB2 (zinc finger RNA-binding splicing regulator), SRSF1 (SR splicing factor), LUC7L3 (pre-mRNA splicing factor), RNF113A (splicing-associated E3 ligase), and CNOT11/CNOT4 (CCR4-NOT deadenylation complex) collectively point to pre-mRNA splicing and mRNA turnover. SENP6 (SUMO protease regulating splicing machinery), GTF2A1, and CREB1 add transcriptional regulation context. The module is uniformly expressed at low levels across gd T subsets, consistent with a constitutive RNA processing program rather than a specific activation state.
Genes
CNOT11, CNOT4, CPNE1, CREB1, GATAD1, GTF2A1, LMBRD1, LUC7L3, METTL23, POLR1H, RNF113A, SENP6, SRSF1, TIMMDC1, TOP3A, USP48, VRK2, ZNF33A, ZRANB2
Most correlated modules
- DNA Damage Repair · correlation 0.86
- Ubiquitin-Proteasome Trafficking · correlation 0.85
- Chromatin TF Regulation · correlation 0.84
- mRNA Decay Trafficking · correlation 0.82
- Rho GTPase Signaling · correlation 0.81
- SR Kinase & RNA · correlation 0.80
- Ubiquitin Protein Quality · correlation 0.79
- Pre-mRNA Splicing · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.