CXCL6 — C-X-C motif chemokine ligand 6
CXCL6 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CXCL6's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Inflammatory Fibroblast Activation Inflammatory | ALPL, ARL4C, CD44, CHST15, DCBLD1, EVA1A, MAP3K5, MICALL2 +4 more | View in SCUBA |
About the gene
| Synonyms | CKA-3, GCP-2, SCYB6 |
|---|---|
| Chromosome | 4: 73836640-73849064 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Predicted secreted proteins |
| Molecular function | Antibiotic, Antimicrobial, Cytokine, Heparin-binding |
| Biological process | Chemotaxis |
Function
Chemotactic for neutrophil granulocytes. Signals through binding and activation of its receptors (CXCR1 and CXCR2). In addition to its chemotactic and angiogenic properties, it has strong antibacterial activity against Gram-positive and Gram-negative bacteria (90-fold-higher when compared to CXCL5 and CXCL7).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.