MAP3K5 — Mitogen-activated protein kinase kinase kinase 5
MAP3K5 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MAP3K5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | NF-kB feedback TCR/AP1/NFKb pathway | ADTRP, AKAP5, CDIP1, CDKN2A, CLEC7A, INPP1, N4BP1, PBXIP1 +8 more | View in SCUBA |
| Enterocytes | Long-gene intronic signal Technical artifact | ASCC3, CASK, KCNQ1, LGR4, MECOM, MID1, PPP1R9A, RALGAPA2 +5 more | View in SCUBA |
| Fibroblasts | Inflammatory Fibroblast Activation Inflammatory | ALPL, ARL4C, CD44, CHST15, CXCL6, DCBLD1, EVA1A, MICALL2 +4 more | View in SCUBA |
| Innate lymphoid cells | ILC3 identity Differentiation | BHLHE40, BRD4, CASK, CITED2, GLUL, GNAS, HECA, IGFBP7 +19 more | View in SCUBA |
| Macrophages | MITF Lysosomal Program Lysosomal & pahgocytosis | ABHD3, ANKRD44, ARSB, C2CD5, CERS6, CHST11, CNST, DCTN4 +25 more | View in SCUBA |
| Neutrophils | Stress Kinase Signaling Stress | ANKRD44, APBB1IP, HIPK3, IGF1R, MEF2A, NEK7, PARP8, RAP1GAP2 +2 more |
About the gene
| Synonyms | ASK1, MAPKKK5, MEKK5 |
|---|---|
| Chromosome | 6: 136557046-136793097 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
| Biological process | Apoptosis, Host-virus interaction, Immunity, Innate immunity, Stress response |
Function
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.