Inflammatory Fibroblast Activation
Gene co-expression module in Fibroblasts
| Category | Inflammatory |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 13 genes have a known function matching the annotation |
Why this annotation
MAP3K5 (ASK1) is a stress-activated MAPK kinase kinase that responds to oxidative stress and inflammatory cytokines. CXCL6 is a neutrophil-attracting chemokine produced by fibroblasts in inflammation. STAT2 is a transcription factor downstream of type I/III interferon signaling. TDO2 encodes tryptophan 2,3-dioxygenase, an immunomodulatory enzyme induced in inflammatory contexts. CHST15 encodes a sulfotransferase involved in chondroitin sulfate biosynthesis/ECM remodeling. CD44 is a cell surface receptor upregulated in activated/inflammatory fibroblasts. NRP2 is a co-receptor for semaphorins and VEGF involved in fibroblast activation. ALPL (alkaline phosphatase) marks a specific fibroblast subset. DCBLD1 is involved in cell migration. EVA1A mediates autophagy and apoptosis. The module is strongly upregulated in CD inflammation. The combination of MAP3K5, CXCL6, STAT2, TDO2, and CD44 suggests an inflammatory fibroblast activation program with immunomodulatory features, particularly prominent in CD.
Genes
ALPL, ARL4C, CD44, CHST15, CXCL6, DCBLD1, EVA1A, MAP3K5, MICALL2, NRP2, RIPOR3, STAT2, TDO2
Most correlated modules
- Inflammatory ECM Remodeling · correlation 0.80
- Interferon Response · correlation 0.77
- Cytokine Chemokine Secretion · correlation 0.77
- OSM Cytokine Response · correlation 0.72
- AP-1 Inflammatory Stress · correlation 0.69
- Activated Myofibroblast State · correlation 0.69
- NF-κB Inflammatory Activation · correlation 0.65
- CCL11 Secretory Fibroblast · correlation 0.64
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.