CYP2C18 — Cytochrome P450 family 2 subfamily C member 18
CYP2C18 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CYP2C18's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | PGC1A/ERRG metabolic program Lipid metabolism | CYP4F12, ENSG00000276490, EPHX2, ESRRG, GIPC2, GLUD1, MATN2, OSBPL6 +6 more | View in SCUBA |
About the gene
| Synonyms | CPCI, CYP2C, CYP2C17, P450IIC17 |
|---|---|
| Chromosome | 10: 94683729-94736190 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Monooxygenase, Oxidoreductase |
| Biological process | Lipid metabolism |
Function
A cytochrome P450 monooxygenase involved in retinoid metabolism. Hydroxylates all trans-retinoic acid (atRA) to 4- hydroxyretinoate and may modulate atRA signaling and clearance. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH- ferrihemoprotein reductase)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.