OSBPL6 — Oxysterol binding protein like 6
OSBPL6 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
OSBPL6's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | PGC1A/ERRG metabolic program Lipid metabolism | CYP2C18, CYP4F12, ENSG00000276490, EPHX2, ESRRG, GIPC2, GLUD1, MATN2 +6 more | View in SCUBA |
About the gene
| Synonyms | ORP6 |
|---|---|
| Chromosome | 2: 178194481-178402893 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
| Biological process | Lipid transport, Transport |
Function
Regulates cellular transport and efflux of cholesterol. Plays a role in phosphatidylinositol-4-phophate (PI4P) turnover at the neuronal membrane (By similarity). Binds via its PH domain PI4P, phosphatidylinositol-4,5-diphosphate, phosphatidylinositol-3,4,5-triphosphate, and phosphatidic acid (By similarity). Weakly binds 25-hydroxycholesterol.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.