PGC1A/ERRG metabolic program
Gene co-expression module in Enterocytes
| Category | Lipid metabolism |
|---|---|
| Genes | 15 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 15 genes have a known function matching the annotation |
Why this annotation
PPARGC1A and ESRRG are master regulators of mitochondrial and oxidative metabolism in colonocytes. They co-occur with CYP4F12, CYP2C18, EPHX2 and UGT2A3, which handle eicosanoid and xenobiotic metabolism, along with GLUD1 and OSBPL6. This describes a PGC1A/ERRG-driven metabolic program in top-of-crypt colonocytes.
Genes
CYP2C18, CYP4F12, ENSG00000276490, EPHX2, ESRRG, GIPC2, GLUD1, MATN2, OSBPL6, PPARGC1A, PRAG1, RMDN2, SHLD2, UGT2A3, VSIG10
Most correlated modules
- Carbohydrate Digestion/Detox · correlation 0.90
- Gluconeogenesis/fructose metabolism · correlation 0.90
- PPARA/FXR fatty acid oxidation · correlation 0.89
- Colonocyte Solute Transport · correlation 0.86
- Brush-border nutrient uptake · correlation 0.86
- Sterol Transfer · correlation 0.86
- Xenobiotic Detoxification · correlation 0.82
- Enterocyte Ion/Nutrient Transport · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.