EDAR — Ectodysplasin A receptor
EDAR belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
EDAR's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Naive resting T cell T cell development | ACTN1, ADD3, ALKBH7, ANKRD55, ARMH1, CEP170, GCNT4, HOOK2 +7 more | View in SCUBA |
| Fibroblasts | Fibroblast Niche Identity Developmental | ALKAL2, AMPD3, CHST1, CNTFR, COL4A6, CTTNBP2, CXCR4, DDHD1 +10 more | View in SCUBA |
About the gene
| Synonyms | DL, ED1R, ED3, ED5, EDA1R, EDA3 |
|---|---|
| Chromosome | 2: 108894471-108989372 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted membrane proteins |
| Molecular function | Developmental protein, Receptor |
| Biological process | Apoptosis, Differentiation |
Function
Receptor for EDA isoform A1, but not for EDA isoform A2. Mediates the activation of NF-kappa-B and JNK. May promote caspase- independent cell death
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.