CXCR4 — C-X-C motif chemokine receptor 4

CXCR4 belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

CXCR4's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	B cell quiescence BCR/AP1/NFKb pathway	AREG, BTG1, CD55, LY9, PNRC1, TUBA1A, YPEL5, ZFP36L2	View in SCUBA
CD4⁺ T cells	Immediate early activation TCR/AP1/NFKb pathway	ALG13, AREG, BCAS2, C9orf72, FAM222A, HIP1R, NR4A2, PABPC1 +18 more	View in SCUBA
Endothelial	CXCL12 Angiogenic Chemotaxis Chemotaxis	ACKR3, AFAP1L1, ARHGAP18, ARHGEF7, CHST1, FHL3, FSCN1, GABRE +15 more	View in SCUBA
Fibroblasts	Fibroblast Niche Identity Developmental	ALKAL2, AMPD3, CHST1, CNTFR, COL4A6, CTTNBP2, DDHD1, EDAR +10 more	View in SCUBA
Gamma-delta T cells	TCR Early Activation TCR Signaling	BTG1, BTG2, CD69, CIRBP, DUSP1, EIF1, ETV3, FOS +15 more
Goblet cells	NF-kB Inflammatory Signaling chromatin regulation & transcription	CD69, DDX21, DUSP2, FOSL2, IRF1, NFKB2, REL, RGCC +5 more	View in SCUBA
Innate lymphoid cells	NK ILC Tissue Homing Homing & TEM	ADGRE5, AKAP13, AREG, ARL4C, ATP1B3, B3GNT7, BTG1, CCDC107 +25 more	View in SCUBA
Mucosal-associated invariant T cell	NF-κB Negative Feedback Immune regulation	ARL4A, BCAS2, CSRNP1, ENSG00000285976, IDS, ITPRIP, NFKBIA, NFKBIB +7 more
Natural Killer cells	AP-1 Immediate Early activation	BTG1, CITED2, DUSP1, DUSP2, FOS, JUN, JUNB, KLF6 +1 more	View in SCUBA

About the gene

Synonyms	CD184, D2S201E, fusin, HM89, HSY3RR, LESTR, NPY3R, NPYR, NPYY3R
Chromosome	2: 136114349-136119177
Predicted location	Membrane
Essential gene	No
Protein class	Cancer-related genes, CD markers, Disease related genes, FDA approved drug targets, G-protein coupled receptors, Human disease related genes, Predicted membrane proteins, Transporters
Molecular function	G-protein coupled receptor, Host cell receptor for virus entry, Receptor, Transducer
Biological process	Host-virus interaction

Function

Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade. Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival (By similarity). (Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) for human immunodeficiency virus-1/HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env- mediated fusion of the virus.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.