CTTNBP2 — Cortactin binding protein 2
CTTNBP2 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CTTNBP2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Venous EC Identity Endothelial cell development | ACTN1, AK4, CCL14, DAPK1, EPB41L3, FAM171A1, IL1R1, LRRC1 +18 more | View in SCUBA |
| Fibroblasts | Fibroblast Niche Identity Developmental | ALKAL2, AMPD3, CHST1, CNTFR, COL4A6, CXCR4, DDHD1, EDAR +10 more | View in SCUBA |
| Monocytes | IL-18 Inflammasome Response Inflammatory | DEPTOR, EPS8, IL18, LHFPL6, ME1, NPL, RNF141, SHMT1 | View in SCUBA |
| Smooth muscle cells | Cytoskeletal Scaffolding Cytoskeletal | AKAP6, C3orf70, CNST, DACT3, IQGAP1, KIF13A, KLHL23, NTF3 +8 more | View in SCUBA |
About the gene
| Synonyms | C7orf8, CORTBP2, KIAA1758, Orf4 |
|---|---|
| Chromosome | 7: 117710651-117874139 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
Function
Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, and thus controls dendritic spinogenesis and dendritic spine maintenance. Associates with the striatin-interacting phosphatase and kinase (STRIPAK) core complex to regulate dendritic spine distribution of the STRIPAK complex in hippocampal neurons
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.