ERBB3 — Erb-b2 receptor tyrosine kinase 3
ERBB3 belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ERBB3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | Nuclear Receptor Signaling Nutrient processing | APLP2, CCNDBP1, CYB5B, EIF4EBP2, HSD17B11, KIAA2013, MGAT4A, MKRN1 +9 more | View in SCUBA |
About the gene
| Synonyms | HER3, LCCS2 |
|---|---|
| Chromosome | 12: 56076799-56103505 |
| Predicted location | Intracellular, Membrane, Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, Transporters |
| Molecular function | Kinase, Receptor, Transferase, Tyrosine-protein kinase |
Function
Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.