Nuclear Receptor Signaling
Gene co-expression module in Colonocytes
| Category | Nutrient metabolism |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 18 genes have a known function matching the annotation |
Why this annotation
RXRA (RXR-alpha nuclear receptor) is a central hub for lipid/metabolic transcriptional regulation in colonocytes. Supporting genes include TXNIP (glucose/redox sensor), EIF4EBP2 (translational repressor downstream of mTOR), ERBB3 (growth factor receptor), PPM1A (phosphatase regulating stress kinases), HSD17B11 (hydroxysteroid dehydrogenase), CYB5B (electron transfer in lipid metabolism), and SORL1 (lipoprotein sorting). The significant CD treatment response (delta_treatment_CD=1.012) suggests this program is modulated by CD therapy. The module reflects nuclear receptor-driven metabolic/lipid signaling in colonocytes, neighboring M113 which also centers on PPARG-lipid metabolism.
Genes
Most correlated modules
- Lysosomal Autophagy Trafficking · correlation 0.88
- Senescent Stress Signaling · correlation 0.85
- Senescent Colonocyte Identity · correlation 0.82
- ESCRT Membrane Remodeling · correlation 0.82
- Brush Border Cytoskeleton · correlation 0.81
- Colonocyte Detoxification · correlation 0.79
- Mature Colonocyte Identity · correlation 0.79
- PPARG Lipid Metabolism · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.