HSD17B11 — Hydroxysteroid 17-beta dehydrogenase 11
HSD17B11 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HSD17B11's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Microvillus actin cytoskeleton Cytoskeletal | CYB5A, PRXL2A, SCIN, SMPD3, TDP2, VIL1 | View in SCUBA |
| Innate lymphoid cells | RNA Processing RNA processing & translation | C1orf56, CD53, CNOT6L, EVI2A, HNRNPH2, MAPRE1, METTL15, NOP53 +3 more | View in SCUBA |
About the gene
| Synonyms | 17-BETA-HSD11, 17-BETA-HSDXI, DHRS8, PAN1B, RetSDR2, SDR16C2 |
|---|---|
| Chromosome | 4: 87336515-87391188 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Oxidoreductase |
| Biological process | Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis |
Function
Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A- dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.