GUCY1A2 — Guanylate cyclase 1 soluble subunit alpha 2
GUCY1A2 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GUCY1A2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Pericytes | Hypoxia NO Signaling Mitochondrial & OxPhos | CAMK2N1, CDH6, COX4I2, EPS8, FAM162B, NDUFA4L2, PMEPA1 | View in SCUBA |
About the gene
| Synonyms | GC-SA2, GUC1A2 |
|---|---|
| Chromosome | 11: 106674019-107018476 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Lyase |
| Biological process | cGMP biosynthesis |
Function
Has guanylyl cyclase on binding to the beta-1 subunit. Isoform 2 acts as a negative regulator of guanylyl cyclase activity as it forms non-functional heterodimers with the beta subunits
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.