Hypoxia NO Signaling
Gene co-expression module in Pericytes
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 8 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 8 genes have a known function matching the annotation |
Why this annotation
COX4I2 and NDUFA4L2 are hypoxia-inducible mitochondrial subunit isoforms specifically upregulated under low oxygen. GUCY1A2 encodes soluble guanylate cyclase alpha2, a key NO/cGMP signaling component in vascular cells. FAM162B is a hypoxia-associated pro-apoptotic protein. PMEPA1 is a TGF-beta/androgen target. CAMK2N1 (CaMKII inhibitor) and CDH6 (cadherin-6) are expressed in pericytes. EPS8 regulates actin dynamics. The co-expression of hypoxia-induced mitochondrial isoforms with NO/cGMP signaling genes suggests a hypoxic pericyte state with compensatory vasodilatory signaling, consistent with the inflamed intestinal microenvironment.
Genes
CAMK2N1, CDH6, COX4I2, EPS8, FAM162B, GUCY1A2, NDUFA4L2, PMEPA1
Most correlated modules
- Pericyte Identity Signaling · correlation 0.86
- Pericyte Identity · correlation 0.79
- Quiescent Pericyte State · correlation 0.78
- Pericyte ECM Production · correlation 0.77
- Pericyte Vascular Tone · correlation 0.74
- Pericyte Identity Differentiation · correlation 0.71
- Focal Adhesion Cytoskeleton · correlation 0.70
- Myosin Phosphatase Regulation · correlation 0.60
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.