Pericytes: gene co-expression modules

Contractile mural cells embracing capillaries within the basement membrane; they stabilise vessels, tune microvascular tone and permeability, and can be recruited into fibrotic and angiogenic programmes.

SCUBA's reference network for Pericytes holds 78 gene modules covering 813 genes. Each module is a group of genes that rise and fall together across these cells, annotated with the biological process it most likely represents.

View the Pericytes network in SCUBA

Cell cycle (1)

• G1 Cell Cycle Entry · 15 genes

Cytoskeletal (15)

• Actin Cytoskeletal Remodeling · 9 genes
• Actin Dynamics · 8 genes
• Actin-ERM Migration · 9 genes
• Caveolae Organization · 8 genes
• Cytoskeletal Remodeling · 9 genes
• ER-Actin Cytoskeletal · 9 genes
• Focal Adhesion Cytoskeleton · 9 genes
• Myosin Phosphatase Regulation · 11 genes
• Pericyte Contractile Tone · 13 genes
• Pericyte Identity · 11 genes
• RAS Cytoskeletal Signaling · 9 genes
• Rho GTPase Signaling · 8 genes
• Smooth Muscle Contractile · 11 genes
• Smooth Muscle Contractile · 11 genes
• TGF-β Cytoskeletal Remodeling · 11 genes

Developmental (21)

• Angiogenic Receptor Signaling · 10 genes
• Arterial Identity TFs · 9 genes
• Arterial Notch Signaling · 10 genes
• Arterial Pericyte Identity · 10 genes
• BMP Receptor Signaling · 10 genes
• BMP-SMAD Signaling · 12 genes
• BMP-Stromal Signaling · 9 genes
• Inflammatory Pericyte Activation · 9 genes
• Notch Vascular Development · 11 genes
• Pericyte Identity · 10 genes
• Pericyte Identity · 9 genes
• Pericyte Identity · 11 genes
• Pericyte Identity Differentiation · 20 genes
• Pericyte Identity Signaling · 8 genes
• Pericyte Vascular Identity · 19 genes
• Pericyte Vascular Tone · 12 genes
• Quiescent Pericyte State · 10 genes
• Vascular Identity TFs · 9 genes
• Vascular Pericyte Identity · 16 genes
• Vascular Quiescence · 10 genes
• YAP/TAZ Mechanosensing · 10 genes

ECM production (7)

• Basement Membrane Assembly · 10 genes
• Basement Membrane Maintenance · 10 genes
• BM Collagen Production · 9 genes
• Fibrillar Collagen Production · 10 genes
• Pericyte ECM Production · 9 genes
• Pericyte ECM Secretion · 12 genes
• Stromal ECM Production · 9 genes

ECM remodeling (6)

• Basement Membrane Remodeling · 11 genes
• EMT-like Remodeling · 11 genes
• Fibrotic ECM Remodeling · 11 genes
• Fibrotic ECM Remodeling · 11 genes
• Inflammatory ECM Remodeling · 14 genes
• Inflammatory ECM Remodeling · 10 genes

Housekeeping (6)

• G-protein Signaling Scaffold · 10 genes
• mRNA Stability Regulation · 8 genes
• Proteostasis Quality Control · 8 genes
• RAS-Chromatin Signaling · 8 genes
• RNA Splicing Processing · 9 genes
• Vascular Tone Homeostasis · 10 genes

Inflammatory (11)

• Complement Regulatory Pericyte · 8 genes
• Cytokine Inflammatory Response · 13 genes
• Immunoproteasome Induction · 12 genes
• MHC-II Antigen Presentation · 13 genes
• NF-kB Chemokine Response · 8 genes
• NF-κB Inflammatory Activation · 8 genes
• NF-κB Inflammatory Response · 12 genes
• Pericyte Inflammatory Activation · 12 genes
• TGF-beta Negative Feedback · 15 genes
• Type I Interferon · 9 genes
• UC Inflammatory Activation · 12 genes

Migration & adhesion (3)

• Vascular Barrier Integrity · 11 genes
• Vascular Junction Adhesion · 11 genes
• Vascular Permeability · 8 genes

Mitochondrial & OxPhos (2)

• Hypoxia NO Signaling · 8 genes
• Mitochondrial OxPhos · 9 genes

Stress (5)

• ER Chaperone UPR · 8 genes
• ER Protein Folding · 10 genes
• ER Stress Response · 9 genes
• Immediate Early Gene · 12 genes
• Proteotoxic Stress Response · 10 genes

Vesicular traficking (1)

• Golgi Vesicular Trafficking · 10 genes