CAMK2N1 — Calcium/calmodulin dependent protein kinase II inhibitor 1
CAMK2N1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CAMK2N1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Mature colonocyte absorptive Absorption | ADI1, BRI3, BTG1, CTSZ, FXYD3, GUCA2A, GUCA2B, HSD17B2 +9 more | View in SCUBA |
| Goblet cells | BMP Signaling Response Epithelial development | CCND2, EIF4A2, GSTA1, GSTA4, ID2, ID3, PDK4, ZBTB10 | View in SCUBA |
| Pericytes | Hypoxia NO Signaling Mitochondrial & OxPhos | CDH6, COX4I2, EPS8, FAM162B, GUCY1A2, NDUFA4L2, PMEPA1 | View in SCUBA |
About the gene
| Synonyms | CaMKIINalpha |
|---|---|
| Chromosome | 1: 20482391-20486210 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Protein kinase inhibitor |
Function
Potent and specific inhibitor of CaM-kinase II (CAMK2) (By similarity). Plays a role in the maintenance of long-term retrieval- induced memory in response to contextual fear (By similarity). Modulates blood pressure and vascular reactivity via regulation of CAMK2 activity in addition to regulation of left ventricular mass (By similarity). Mediates the NLRP3 inflammasome in cardiomyocytes via acting as an inhibitor of the MAPK14/p38 and MAPK8/JNK pathways, thereby regulating ventricular remodeling and cardiac rhythm post- myocardial infarction (By similarity). Negatively effects insulin sensitivity and promotes lipid formation in adipose tissues independent of CAMK2 signaling (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.