HERC3 — HECT and RLD domain containing E3 ubiquitin protein ligase 3
HERC3 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HERC3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Mixed Regulatory Signaling Housekeeping | ADAP2, AKAP11, ARHGAP17, ARHGAP27, BLTP2, BLTP3A, C2CD2L, COG2 +30 more | View in SCUBA |
About the gene
| Synonyms | KIAA0032 |
|---|---|
| Chromosome | 4: 88592434-88708541 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Transferase |
| Biological process | Ubl conjugation pathway |
Function
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.