Mixed Regulatory Signaling
Gene co-expression module in Macrophages
| Category | Housekeeping |
|---|---|
| Genes | 39 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 7 of 39 genes have a known function matching the annotation |
Why this annotation
This module is weakly coherent with diverse gene functions. Hub genes include ZNF106 (zinc finger RNA-binding), LNPEP (leucyl/cystinyl aminopeptidase, angiotensin processing), BLTP2/BLTP3A (bridge-like lipid transfer proteins), AKAP11 (A-kinase anchoring), MKNK1 (MAP kinase-interacting kinase, translation regulation), LRRC8C (volume-regulated anion channel), KMT2A (histone methyltransferase), NAIP (NLR family apoptosis inhibitory protein, innate immunity), IDS (iduronate-2-sulfatase, lysosomal enzyme), ARHGAP17 (Rho GAP), SLC12A7 (potassium-chloride cotransporter), SMARCC2 (SWI/SNF chromatin remodeling), SLC39A10 (zinc transporter). The module is highly heterogeneous. NAIP is an innate immune sensor (NLR family), IDS is lysosomal, SMARCC2/KMT2A are chromatin regulators. No single dominant program emerges. The presence of NAIP and IDS alongside chromatin and signaling genes suggests a mixed housekeeping/regulatory module. Given the neighbor context of RNA processing modules, this may represent a loosely co-regulated general regulatory program. The best unifying theme among the most represented genes is broad intracellular regulatory/signaling functions.
Genes
ADAP2, AKAP11, ARHGAP17, ARHGAP27, BLTP2, BLTP3A, C2CD2L, COG2, DELE1, DPP9, DUSP6, GOPC, HERC3, ICE2, IDS, KIN, KLHL36, KMT2A, LNPEP, LRRC8C, MBD6, MKNK1, MPHOSPH8, NAIP, NUMA1, PBX2, PHACTR2, PPARA, RIPOR1, RSBN1L, SEPTIN9, SLC12A7, SLC39A10, SMARCC2, TMEM106A, UBN2, WASF2, ZNF106, ZNF217
Most correlated modules
- General Cellular Maintenance · correlation 0.94
- Splicing Factor Regulation · correlation 0.94
- Chromatin Transcriptional Regulation · correlation 0.94
- DNA Damage Repair · correlation 0.92
- RNA Splicing Processing · correlation 0.92
- TGF-beta Signaling · correlation 0.92
- Anti-inflammatory Response · correlation 0.91
- Pre-mRNA Splicing · correlation 0.91
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.