ADAP2 — ArfGAP with dual PH domains 2
ADAP2 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ADAP2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Mixed Regulatory Signaling Housekeeping | AKAP11, ARHGAP17, ARHGAP27, BLTP2, BLTP3A, C2CD2L, COG2, DELE1 +30 more | View in SCUBA |
| Monocytes | M2 Macrophage Polarization Tissue homeostasis | ABCC5, ARHGAP18, CD84, FRMD4B, GNPDA1, LIPA, MAF, MRC1 | View in SCUBA |
| Pericytes | Pericyte Vascular Tone Developmental | CHCHD10, CSPG4, FOXS1, LINGO1, MCAM, MFGE8, PGF, PTGIR +3 more | View in SCUBA |
| Smooth muscle cells | Capillary Pericyte Development | ADRA2A, ANKRD29, CCL8, CNGA1, ENPEP, EPHA2, EPS8L1, FAM162B +10 more | View in SCUBA |
About the gene
| Synonyms | CENTA2 |
|---|---|
| Chromosome | 17: 30906344-30959322 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | GTPase activation |
Function
GTPase-activating protein for the ADP ribosylation factor family (Potential). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Possesses a stoichiometry of two binding sites for InsP4 with identical affinity
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.