HSPBP1 — HSPA (Hsp70) binding protein 1
HSPBP1 belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HSPBP1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | Spliceosome Assembly RNA processing & translation | FLOT2, FTSJ3, HNRNPL, HUWE1, LARP1, POLR2B, PRPF8, SCAMP3 +1 more | View in SCUBA |
About the gene
| Synonyms | FES1 |
|---|---|
| Chromosome | 19: 55262223-55280381 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of immature CFTR.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.