Spliceosome Assembly
Gene co-expression module in Colonocytes
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 6 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes PRPF8 and SNRNP200 are core spliceosomal components (U5 snRNP), POLR2B is RNA Polymerase II subunit, HNRNPL is a splicing regulator, FTSJ3 is an rRNA/snRNA methyltransferase, and LARP1 regulates mRNA stability. FLOT2 and SCAMP3 are membrane-associated but show core membership, likely co-regulated housekeeping genes. The module is tightly coherent with uniform expression across colonocyte subsets, consistent with a constitutive spliceosome/transcription program.
Genes
Most correlated modules
- Chromatin-Coupled Splicing · correlation 0.86
- DNA Repair Housekeeping · correlation 0.86
- Mitochondrial Biogenesis · correlation 0.84
- ER Stress & Lipid Metabolism · correlation 0.84
- Pre-mRNA Splicing · correlation 0.83
- Mitochondrial Biogenesis · correlation 0.83
- Colonocyte Differentiation · correlation 0.81
- ER-Golgi Trafficking · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.