LARP1 — La ribonucleoprotein 1, translational regulator
LARP1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LARP1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Nuclear Pore Organization Housekeeping | AIDA, DHX8, H4C6, LBR, MPRIP, MTR, NNT, NUP155 +14 more | |
| Macrophages | Autophagy Vesicular Trafficking Vesicular traficking | ACTR2, AHCYL1, ALKBH5, BECN1, BICD2, CAP1, CAPRIN1, COLGALT1 +32 more | View in SCUBA |
About the gene
| Synonyms | KIAA0731, Lar1, LARP, Lhp1, MGC19556 |
|---|---|
| Chromosome | 5: 154682986-154817605 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
| Molecular function | Repressor, RNA-binding |
| Biological process | Protein biosynthesis, Translation regulation |
Function
RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability. Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery. The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1. When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA. Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif. Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes. Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis. Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation. Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis. (Microbial infection) Positively regulates the replication of dengue virus (DENV)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.