FLOT2 — Flotillin 2
FLOT2 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FLOT2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Oxidative Stress Response Stress | AHR, CD151, CD59, CTTNBP2NL, DSTN, GNB4, GNG5, HYAL2 +11 more | View in SCUBA |
| Gamma-delta T cells | Coinhibitory Checkpoint Exhaustion | BTN3A2, CDC25B, CDC42EP3, DDTL, FAM117A, GBP5, GGPS1, GRAP2 +12 more | |
| Macrophages | Monocyte Phagocytic Identity Lysosomal & pahgocytosis | CD14, CD99, CMTM3, DUSP3, FCGR2A, INF2, MARVELD1, PLAU +7 more | View in SCUBA |
| Monocytes | Pentose Phosphate Pathway Innate immunity | ACAP1, AP5B1, CCDC69, CCND3, CITED4, CORO2A, DYSF, EIF4E3 +4 more | View in SCUBA |
| Mucosal-associated invariant T cell | Cytoskeletal Remodeling Migration migration & adhesion | ADAM8, BIN2, C11orf21, CAPN1, CAPN2, CD52, CDC25B, CNN2 +14 more | |
| Neutrophils | Endosomal Vesicle Trafficking Vesicular traficking | FKBP5, IQGAP1, MYO1F, RGS18, RIPOR2, SMAP2, SORL1 |
About the gene
| Synonyms | ECS-1, ECS1, ESA, ESA1, M17S1 |
|---|---|
| Chromosome | 17: 28879335-28897733 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
| Biological process | Cell adhesion |
Function
May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.