IDH3G — Isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma
IDH3G belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
IDH3G's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | General Housekeeping Mixed Housekeeping | ARPC3, CHCHD5, COPZ1, DRAP1, NDUFB10, OSTC, POLR2G, PPP1R7 +4 more |
About the gene
| Chromosome | X: 153785766-153794512 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Citric acid cycle related proteins, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Biological process | Tricarboxylic acid cycle |
Function
Regulatory subunit which plays a role in the allosteric regulation of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.