General Housekeeping Mixed
Gene co-expression module in Gamma-delta T cells
| Category | Housekeeping |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 13 genes have a known function matching the annotation |
Why this annotation
This module includes COPZ1 (COPI vesicle coat), OSTC (oligosaccharyltransferase complex), NDUFB10 (NADH:ubiquinone oxidoreductase), IDH3G (isocitrate dehydrogenase, TCA cycle), SDHC (succinate dehydrogenase complex, Complex II), CHCHD5 (mitochondrial intermembrane space), ARPC3 (Arp2/3 complex actin nucleation), SSNA1 (centrosome/microtubule), ZNHIT1 (chromatin remodeling/H2A.Z), PPP1R7 (PP1 regulatory subunit), ZNF428 (zinc finger transcription factor), DRAP1 (transcriptional corepressor), and POLR2G (RNA pol II subunit). The module combines mitochondrial/metabolic (NDUFB10, IDH3G, SDHC, CHCHD5), vesicle trafficking (COPZ1, OSTC), and transcriptional/chromatin regulation (ZNHIT1, DRAP1, POLR2G) functions—a broad housekeeping cluster. No lineage-specific enrichment. As a neighbor to M70 and M174, this fits into a cluster of constitutive housekeeping programs.
Genes
ARPC3, CHCHD5, COPZ1, DRAP1, IDH3G, NDUFB10, OSTC, POLR2G, PPP1R7, SDHC, SSNA1, ZNF428, ZNHIT1
Most correlated modules
- Cytotoxic Effector Actin · correlation 0.93
- Oxidative Phosphorylation · correlation 0.90
- Basal Cell Maintenance · correlation 0.89
- Complex I Assembly · correlation 0.89
- Glycolysis & Proteasome · correlation 0.88
- Mitochondrial Housekeeping · correlation 0.87
- Protein Homeostasis Chaperones · correlation 0.87
- Transcriptional Elongation Control · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.