KMT2D — Lysine methyltransferase 2D
KMT2D belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
KMT2D's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Hippo Pathway Signaling TCR Signaling | ADAR, ARL8B, BAZ2A, CASC3, CCDC85C, CCNK, CDC73, CDK12 +24 more |
About the gene
| Synonyms | ALR, CAGL114, MLL2, MLL4, TNRC21 |
|---|---|
| Chromosome | 12: 49018975-49060794 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Chromatin regulator, Methyltransferase, Transferase |
| Biological process | Transcription, Transcription regulation |
Function
Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.