CCNK — Cyclin K
CCNK belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CCNK's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Hippo Pathway Signaling TCR Signaling | ADAR, ARL8B, BAZ2A, CASC3, CCDC85C, CDC73, CDK12, CSDE1 +24 more | |
| Macrophages | RNA Processing Regulation Housekeeping | ACBD3, AQR, ARCN1, BFAR, BNIP3L, CCNI, DIS3, DNAJC3 +15 more | View in SCUBA |
| Mucosal-associated invariant T cell | Co-transcriptional Splicing RNA processing & translation | C9orf78, CCDC85C, CDKN1B, DNTTIP2, EIF4B, ILF3, LAPTM5, MADD +16 more |
About the gene
| Synonyms | CPR4 |
|---|---|
| Chromosome | 14: 99481169-99535044 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Essential proteins, Human disease related genes, Predicted intracellular proteins |
| Molecular function | Cyclin |
| Biological process | Cell cycle, Cell division, Host-virus interaction, Mitosis, Transcription, Transcription regulation |
Function
Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C- terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.