Hippo Pathway Signaling
Gene co-expression module in Gamma-delta T cells
| Category | TCR Signaling |
|---|---|
| Genes | 33 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 14 of 33 genes have a known function matching the annotation |
Why this annotation
LATS1 and MOB1A are the core kinase-cofactor pair of the Hippo signaling pathway, which controls organ size, cell proliferation, and apoptosis. CCNK (cyclin K) regulates transcription-associated CDK9/CDK12. SNRNP200 and PRPF8 are spliceosome components. NCL (nucleolin) is involved in ribosome biogenesis and cell growth. ADAR performs RNA editing. WIPF1 and MYH9 link to actin cytoskeletal organization. The Hippo pathway components LATS1/MOB1A drive the module's identity, with splicing and chromatin regulators co-expressed in proliferating/growth-state T cells. Core coherence supports a tight program.
Genes
ADAR, ARL8B, BAZ2A, CASC3, CCDC85C, CCNK, CDC73, CDK12, CSDE1, DPP9, EXOC8, HNRNPU, KAT7, KMT2D, LATS1, MOB1A, MYH9, NCL, OGA, PRPF8, PUM1, QRICH1, RNF216, RNF6, SLC25A32, SMARCA5, SNRNP200, TPP2, UBQLN1, UBR4, WIPF1, YLPM1, ZNF460
Most correlated modules
- Transcription-RNA Coupling · correlation 0.94
- Chromatin Epigenetic Regulation · correlation 0.91
- T cell Identity Signaling · correlation 0.85
- Wnt-STAT3 Signaling · correlation 0.84
- Vesicular Trafficking · correlation 0.84
- Translation & Proteostasis · correlation 0.82
- Hypoxia Stress Response · correlation 0.82
- DNA Damage Response · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.