BAZ2A — Bromodomain adjacent to zinc finger domain 2A
BAZ2A belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BAZ2A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Hippo Pathway Signaling TCR Signaling | ADAR, ARL8B, CASC3, CCDC85C, CCNK, CDC73, CDK12, CSDE1 +24 more | |
| Macrophages | DNA Damage Repair Stress | ABCC5, ADAM28, AKAP9, AKNA, ATM, ATP10D, CHD9, CREBRF +27 more | View in SCUBA |
| Mucosal-associated invariant T cell | Chromatin & Splicing DNA/chromatin regulation | ACIN1, ADAR, API5, CDC73, CDK12, COPA, FUBP1, KAT7 +11 more |
About the gene
| Synonyms | KIAA0314, TIP5, WALp3 |
|---|---|
| Chromosome | 12: 56595596-56636816 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
| Molecular function | Chromatin regulator, DNA-binding, Repressor, RNA-binding |
| Biological process | Transcription, Transcription regulation |
Function
Regulatory subunit of the ATP-dependent NoRC-1 and NoRC-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair. Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template. Directly stimulates the ATPase activity of SMARCA5 in the NoRC-5 ISWI chromatin remodeling complex. The NoRC-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NoRC-5 ISWI chromatin remodeling complex. Within the NoRC-5 ISWI chromatin remodeling complex, mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity). In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription (By similarity). Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac (By similarity). Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.