L1CAM — L1 cell adhesion molecule
L1CAM belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
L1CAM's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Glial cells | Matricellular ECM Homeostasis ECM remodeling | FSTL1, MARCKS, MARVELD1, MATN2, SEMA3B, SPARC, SPARCL1 | View in SCUBA |
About the gene
| Synonyms | CAML1, CD171, HSAS, HSAS1, MASA, MIC5, NCAM-L1, S10, SPG1 |
|---|---|
| Chromosome | X: 153861514-153886173 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | CD markers, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Developmental protein |
| Biological process | Cell adhesion, Differentiation, Neurogenesis |
Function
Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neuronal migration, axonal growth and fasciculation, and synaptogenesis. In the mature brain, plays a role in the dynamics of neuronal structure and function, including synaptic plasticity
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.