SCUBA

FSTL1 — Follistatin like 1

FSTL1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

FSTL1's module in each cell type

Cell typeModuleShares the module with
EndothelialInflammatory Endothelial Activation
Inflammation		ANXA6, CNIH1, COTL1, DEGS1, DHRS7, F2R, FKBP10, JAK1 +8 moreView in SCUBA
FibroblastsCollagen ECM Production
ECM production		AEBP1, ANGPTL2, ANTXR1, CERCAM, CLTC, COL1A1, COL1A2, COL3A1 +12 moreView in SCUBA
Glial cellsMatricellular ECM Homeostasis
ECM remodeling		L1CAM, MARCKS, MARVELD1, MATN2, SEMA3B, SPARC, SPARCL1View in SCUBA
PericytesFibrotic ECM Remodeling
ECM remodeling		ADAMTS12, ADAMTS2, CD248, COL12A1, COL5A2, LOXL2, NID2, PAMR1 +2 moreView in SCUBA
Smooth muscle cellsCollagen Biosynthesis
ECM remodeling		CALU, COL1A1, COL1A2, COL3A1, COL4A1, COL4A2, COL6A1, COL6A2 +4 moreView in SCUBA

About the gene

SynonymsFRP, FSL1, OCC-1, OCC1, tsc36
Chromosome3: 120392293-120450993
Predicted locationIntracellular, Secreted
Essential geneNo
Protein classPlasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Molecular functionHeparin-binding

Function

Secreted glycoprotein that is involved in various physiological processes, such as angiogenesis, regulation of the immune response, cell proliferation and differentiation. Plays a role in the development of the central nervous system, skeletal system, lungs, and ureter (By similarity). Promotes endothelial cell survival, migration and differentiation into network structures in an AKT-dependent manner. Also promotes survival of cardiac myocytes (By similarity). Initiates various signaling cascades by activating different receptors on the cell surface such as DIP2A, TLR4 or BMP receptors.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.