SPARC — Secreted protein acidic and cysteine rich
SPARC belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SPARC's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Basement Membrane Assembly ECM remodeling | COL15A1, COL4A1, COL4A2, HSPG2, KIFC3, MGAT4A, NDST1, NOL4L +4 more | View in SCUBA |
| Fibroblasts | Collagen ECM Production ECM production | AEBP1, ANGPTL2, ANTXR1, CERCAM, CLTC, COL1A1, COL1A2, COL3A1 +12 more | View in SCUBA |
| Glial cells | Matricellular ECM Homeostasis ECM remodeling | FSTL1, L1CAM, MARCKS, MARVELD1, MATN2, SEMA3B, SPARCL1 | View in SCUBA |
| Macrophages | Hypoxia Stress Response Stress | ACE, AMPD3, APP, ASPH, BCAT1, BEX3, BHLHE41, BNIP3 +34 more | View in SCUBA |
| Pericytes | BM Collagen Production ECM production | ANGPT2, COL18A1, COL4A1, COL4A2, COL5A3, ITGA1, MEST, PXDN | View in SCUBA |
About the gene
| Synonyms | BM-40, ON, ONT |
|---|---|
| Chromosome | 5: 151661096-151686975 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins |
Function
Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.