Glial cells: gene co-expression modules

Enteric glia derived from neural crest, ensheathing the gut’s intrinsic neurons; they support neurotransmission, reinforce barrier function, and modulate motility and mucosal immune signalling.

SCUBA's reference network for Glial cells holds 73 gene modules covering 786 genes. Each module is a group of genes that rise and fall together across these cells, annotated with the biological process it most likely represents.

View the Glial cells network in SCUBA

Activation (6)

• AHR-Cytokine Activation · 10 genes
• Enteric Glial Identity · 10 genes
• Immediate Early Gene Response · 12 genes
• Reactive Glial Activation · 9 genes
• Reactive Glial Activation · 11 genes
• S100 Glial Activation · 8 genes

Cytoskeletal (5)

• Actin Cytoskeletal Organization · 10 genes
• Cytoskeletal Glial Homeostasis · 10 genes
• Glial Cytoskeletal Homeostasis · 9 genes
• Glial Neural Scaffolding · 9 genes
• Neural Migration Scaffold · 10 genes

Development (5)

• ENS Developmental TFs · 11 genes
• Enteric Glial Identity · 8 genes
• Glial Homeostatic Identity · 9 genes
• Glial Progenitor Identity · 8 genes
• Glial Quiescence State · 9 genes

ECM remodeling (7)

• Basement Membrane Adhesion · 8 genes
• Collagen ECM Deposition · 11 genes
• ECM Homeostatic Regulation · 8 genes
• Glial ECM Scaffold · 10 genes
• Hyaluronan-CD44 Remodeling · 8 genes
• Matricellular ECM Homeostasis · 8 genes
• TGF-beta ECM Remodeling · 8 genes

Housekeeping (5)

• Enteric Glial Homeostasis · 14 genes
• Glial Identity Homeostasis · 11 genes
• Glial Vesicle Trafficking · 10 genes
• Lysosomal Sphingolipid Metabolism · 9 genes
• Rho GTPase Signaling · 14 genes

Inflammation (9)

• COX-2/NF-κB Inflammation · 8 genes
• IFN-gamma Effector Program · 14 genes
• Inflammatory Activation Response · 12 genes
• Inflammatory Cytokine Signaling · 12 genes
• MHC-I Antigen Presentation · 13 genes
• MHC-II Antigen Presentation · 12 genes
• NF-κB/IFN Inflammatory · 13 genes
• TGF-beta Response · 10 genes
• Type I/II Interferon Response · 15 genes

migration & adhesion (3)

• Actin Remodeling Migration · 8 genes
• Glial Adhesion Cytoskeletal · 10 genes
• Glial Adhesion Identity · 11 genes

Mitochondrial & OxPhos (3)

• ER-Mitochondria Housekeeping · 11 genes
• Mitochondrial Housekeeping · 12 genes
• Mitochondrial OxPhos Integrity · 9 genes

Myelination (4)

• Glial Myelination Identity · 15 genes
• Myelinating Schwann Cell · 10 genes
• Peripheral Glial Myelination · 16 genes
• Peripheral Nerve Myelination · 9 genes

Neroprotection (6)

• BMP-SMAD Signaling · 12 genes
• ER Membrane Homeostasis · 10 genes
• Glial Neuroprotective Response · 13 genes
• Glial Synaptic Adhesion · 10 genes
• Mature Glial Identity · 10 genes
• Neuroprotective Secretory · 10 genes

Protein processing & ER (2)

• ER Translocon Activity · 12 genes
• Proteasomal Proteostasis · 12 genes

RNA processing & translation (5)

• Glial RNA Homeostasis · 8 genes
• Nascent Polypeptide Translation · 11 genes
• RNA Splicing Processing · 11 genes
• RNA Splicing Regulation · 11 genes
• RNA Translation Processing · 14 genes

Stress (13)

• Anti-proliferative mRNA Decay · 13 genes
• Antioxidant Stress Response · 10 genes
• DNA Damage Response · 10 genes
• ER Stress Response · 13 genes
• Glucocorticoid Stress Recovery · 12 genes
• Glutathione Detoxification · 10 genes
• Hypoxia mTOR Stress · 12 genes
• Integrated Stress Response · 12 genes
• Integrated Stress Response · 11 genes
• Metallothionein Stress Response · 10 genes
• Oxidative Stress Response · 12 genes
• Proteostasis Stress Response · 16 genes
• Proteostasis Stress Response · 9 genes