MACROD2 — Mono-ADP ribosylhydrolase 2
MACROD2 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MACROD2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Stromal Niche Identity Developmental | ADAMTS6, CNTNAP3B, HHIP, MYOCD, NELL1, RALGPS2, RPE65 | View in SCUBA |
About the gene
| Synonyms | C20orf133, dJ631M13.5 |
|---|---|
| Chromosome | 20: 13995369-16053197 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase |
| Biological process | DNA damage |
Function
Removes ADP-ribose from aspartate and glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.