Stromal Niche Identity
Gene co-expression module in Fibroblasts
| Category | Developmental |
|---|---|
| Genes | 8 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 4 of 8 genes have a known function matching the annotation |
Why this annotation
MYOCD (myocardin, master smooth muscle/myofibroblast TF), HHIP (canonical HHIP+ intestinal stromal subpopulation marker), ADAMTS6 (ECM metalloprotease), and NELL1 (mesenchymal morphogen) together define a specialized quiescent stromal/smooth muscle-like fibroblast identity. Strong upregulation in remission (delta_remission_CD: 0.652) supports a homeostatic, non-inflammatory fibroblast state. HHIP specifically marks a known intestinal fibroblast subset involved in Hedgehog-mediated niche signaling.
Genes
ADAMTS6, CNTNAP3B, HHIP, MACROD2, MYOCD, NELL1, RALGPS2, RPE65
Most correlated modules
- Smooth Muscle Identity · correlation 0.89
- Myofibroblast Contractile · correlation 0.85
- BMP-Wnt Niche Signaling · correlation 0.84
- TGF-beta Fibroblast Niche · correlation 0.82
- Notch Fibroblast Activation · correlation 0.77
- Focal Adhesion ECM · correlation 0.75
- Caveolae Mechanosensing · correlation 0.75
- Smooth Muscle Differentiation · correlation 0.67
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.