RALGPS2 — Ral GEF with PH domain and SH3 binding motif 2
RALGPS2 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RALGPS2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Chromatin Regulation DNA/chromatin regulation | AKAP9, ANKRD12, BBX, CHD2, CHD7, IRF1, KDM7A, L3MBTL3 +8 more | View in SCUBA |
| CD4⁺ T cells | Naive resting T cell T cell development | ACTN1, ADD3, ALKBH7, ANKRD55, ARMH1, CEP170, EDAR, GCNT4 +7 more | View in SCUBA |
| Fibroblasts | Stromal Niche Identity Developmental | ADAMTS6, CNTNAP3B, HHIP, MACROD2, MYOCD, NELL1, RPE65 | View in SCUBA |
| Glial cells | Glial Adhesion Cytoskeletal migration & adhesion | AKAP9, COL21A1, DOCK5, EPB41L2, KIAA1217, LTBP3, NCAM1, SCN7A +1 more | View in SCUBA |
| Pericytes | Pericyte Identity Differentiation Developmental | ADAMTS5, ARHGAP15, EPB41L2, GUCY1A1, INPP4B, LGI4, LMOD1, MAP1LC3A +11 more | View in SCUBA |
About the gene
| Synonyms | FLJ10244, FLJ25604, KIAA0351 |
|---|---|
| Chromosome | 1: 178725165-178921842 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Predicted intracellular proteins |
| Molecular function | Guanine-nucleotide releasing factor |
Function
Guanine nucleotide exchange factor for the small GTPase RALA. May be involved in cytoskeletal organization. May also be involved in the stimulation of transcription in a Ras-independent fashion (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.