NAA15 — N-alpha-acetyltransferase 15, NatA auxiliary subunit
NAA15 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NAA15's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Ribosome Biogenesis Cell cycle | ACAT1, ANAPC5, CFDP1, IKBIP, MGME1, MGMT, NAA25, NOP58 +8 more | View in SCUBA |
About the gene
| Synonyms | FLJ13340, NARG1, NATH, TBDN100 |
|---|---|
| Chromosome | 4: 139301446-139420033 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Essential proteins, Human disease related genes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Developmental protein |
| Biological process | Angiogenesis, Differentiation, Transcription, Transcription regulation |
Function
Auxillary subunit of N-terminal acetyltransferase complexes which display alpha (N-terminal) acetyltransferase (NAT) activity. The NAT activity may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.