NOP58 — NOP58 ribonucleoprotein
NOP58 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NOP58's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Actin cytoskeleton remodeling Cytoskeletal | ACTR2, BASP1, CAPZA1, CDV3, EIF3A, FAM107B, GRB2, HCLS1 +9 more | View in SCUBA |
| Gamma-delta T cells | hnRNP Splicing Complex RNA processing & translation | ASXL1, DDX21, HNRNPA1, HNRNPC, HNRNPH3, HSPA9, PABPC1, PAPOLA +5 more | |
| Hematopoietic progenitor cells | Ribosome Biogenesis Housekeeping | DDX21, DKC1, GNL3, HNRNPAB, LRPPRC, NOLC1, NOP56, PA2G4 +2 more | |
| Innate lymphoid cells | TRiC Chaperonin Folding Protein processing & ER | ATP6V0D1, CACYBP, CCT2, CCT3, CCT4, CCT5, EIF5A, ELOC +9 more | View in SCUBA |
| Macrophages | Ribosome Biogenesis Cell cycle | ACAT1, ANAPC5, CFDP1, IKBIP, MGME1, MGMT, NAA15, NAA25 +8 more | View in SCUBA |
| Mucosal-associated invariant T cell | mRNA 3' Processing RNA processing & translation | ATXN2L, CD6, DNM2, EIF4A2, HNRNPDL, MLLT6, RBM15B, RNF10 +3 more |
About the gene
| Synonyms | HSPC120, NOP5 |
|---|---|
| Chromosome | 2: 202265736-202303661 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Ribonucleoprotein |
| Biological process | Ribosome biogenesis |
Function
Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.