ANAPC5 — Anaphase promoting complex subunit 5
ANAPC5 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ANAPC5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | mRNA splicing RNA processing | C11orf58, C1orf43, DDX46, DNAJC7, HSPA4, LSM14A, LUC7L3, MRPL47 +8 more | View in SCUBA |
| Gamma-delta T cells | Vesicular Trafficking Housekeeping | ADD1, COPG1, EFCAB14, EXOC7, GANAB, MAN2B2, MCM3AP, MED1 +10 more | |
| Macrophages | Ribosome Biogenesis Cell cycle | ACAT1, CFDP1, IKBIP, MGME1, MGMT, NAA15, NAA25, NOP58 +8 more | View in SCUBA |
| Mucosal-associated invariant T cell | ER Protein Glycosylation Protein processing & ER | HNRNPM, LMAN2, PDAP1, PKM, PRKCSH, RHOA, RPN1, RPN2 +3 more |
About the gene
| Synonyms | APC5 |
|---|---|
| Chromosome | 12: 121308245-121399896 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Biological process | Cell cycle, Cell division, Mitosis, Ubl conjugation pathway |
Function
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.