Ribosome Biogenesis
Gene co-expression module in Macrophages
| Category | Cell cycle |
|---|---|
| Genes | 17 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 12 of 17 genes have a known function matching the annotation |
Why this annotation
Module is enriched in prolif_mac. Hub genes NOP58, WDR43, and RIOK1 are core ribosome biogenesis factors; NUP93 is a nuclear pore component required for rRNA export; ANAPC5 is part of the APC/C cell cycle complex; RNASEH2B supports DNA replication; MGMT is a DNA repair enzyme; MGME1 maintains mitochondrial DNA during replication; NAA15/NAA25 form the NatA N-terminal acetyltransferase complex active in proliferating cells; RBMX is an RNA-binding protein upregulated in proliferation. The convergence of ribosome biogenesis, nuclear pore, APC/C, and DNA maintenance genes in proliferating macrophages defines this as a ribosome biogenesis/cell cycle support module.
Genes
ACAT1, ANAPC5, CFDP1, IKBIP, MGME1, MGMT, NAA15, NAA25, NOP58, NUP93, PPA2, PUM3, RBMX, RIOK1, RNASEH2B, SLC25A40, WDR43
Most correlated modules
- Ribosome Biogenesis · correlation 0.93
- Central Carbon Metabolism · correlation 0.91
- Centrosome & DNA Repair · correlation 0.90
- Myeloid Differentiation Identity · correlation 0.90
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.