NPC1L1 — NPC1 like intracellular cholesterol transporter 1
NPC1L1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NPC1L1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Dietary lipid absorption Absorption | ABCG5, ASAH2, BCO1, CD36, ENPP7, GATA4, LCT, LIN52 +3 more | View in SCUBA |
About the gene
| Synonyms | SLC65A2 |
|---|---|
| Chromosome | 7: 44512535-44541330 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | FDA approved drug targets, Metabolic proteins, Predicted membrane proteins, Transporters |
| Biological process | Cholesterol metabolism, Lipid metabolism, Steroid metabolism, Sterol metabolism, Transport |
Function
Plays a major role in cholesterol homeostasis. Critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Involved in plant sterol absorption, it transports sitosterol, although at lower rates than cholesterol (By similarity). Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption and is approved for the treatment of hypercholesterolemia. May have a function in the transport of multiple lipids and their homeostasis, thereby influencing lipid metabolism regulation. May be involved in caveolin trafficking from the plasma membrane (By similarity). In addition, acts as a negative regulator of NPC2 and down-regulates its expression and secretion by inhibiting its maturation and accelerating its degradation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.