Dietary lipid absorption
Gene co-expression module in Enterocytes
| Category | Absorption |
|---|---|
| Genes | 12 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 12 genes have a known function matching the annotation |
Why this annotation
This is a classic small-intestinal lipid and nutrient absorption program, driven by GATA4-dependent proximal identity. It includes CD36, NPC1L1 and ABCG5 for lipid and sterol handling, ASAH2 and ENPP7 for sphingolipid digestion, LCT (lactase), and BCO1 (beta-carotene cleavage). UGT2B7 and TM4SF4 support the program. Low detection in colon suggests either ileal-like or metaplastic enterocytes, or ileal samples.
Genes
ABCG5, ASAH2, BCO1, CD36, ENPP7, GATA4, LCT, LIN52, NPC1L1, NPNT, TM4SF4, UGT2B7
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.