PIGN — Phosphatidylinositol glycan anchor biosynthesis class N
PIGN belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PIGN's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Myeloid Differentiation Identity Developmental | ADCK2, ALOX5, ATP2C1, CCDC6, CDK6, CMTM7, DEF6, EEF2K +21 more | View in SCUBA |
About the gene
| Synonyms | MCD4, PIG-N |
|---|---|
| Chromosome | 18: 61905255-62187118 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Transferase |
| Biological process | GPI-anchor biosynthesis |
Function
Ethanolamine phosphate transferase that catalyzes an ethanolamine phosphate (EtNP) transfer from phosphatidylethanolamine (PE) to the 2-OH position of the first alpha-1,4-linked mannose of the alpha-D-Man-(1->6)-alpha-D-Man-(1->4)-alpha-D-GlcN-(1->6)-(1-radyl,2- acyl-sn-glycero-3-phospho)-2-acyl-inositol (also termed H3) intermediate to generate an alpha-D-Man-(1->6)-2-PEtn-alpha-D-Man- (1->4)-alpha-D-GlcN-(1->6)-(1-radyl,2-acyl-sn-glycero-3-phospho)-2- acyl-inositol and participates in the eighth step of the glycosylphosphatidylinositol-anchor biosynthesis (By similarity). May act as suppressor of replication stress and chromosome missegregation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.